Callaway County is blessed with good neighbors, all around. Audrain county is to the North and Montgomery to the East. Cole county is separated from Callaway to the South by the Missouri river and Boone county is to the West.
- Columbia is the county seat and the largest community in Boone county. Columbia is the home of the University of Missouri – Columbia, Stephens College and Columbia College.
- Jefferson City, the Missouri state capital, is also the county seat for Cole county and home for Lincoln University.
- Mexico is the county seat and the largest community in Audrain county. It is also the home of Missouri Military Academy and site of the annual Miss Missouri Pageant.